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Physiological effects of VDR

This gene encodes the nuclear hormone receptor for vitamin D3.Downstream targets of this nuclear hormone receptor are involved principally in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.The vitamin D receptor plays an important role in regulating the hair cycle. Loss of VDR is associated with hair loss in experimental animals.

Potential applications of VDR-hinge

VDR-hinge can be fused between any DBDs and LBDs to increase the efficiency gene expression caused by the nuclear receptor itself.

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